Rptor Gene Summary [Rat]
Enables protein kinase binding activity. Involved in positive regulation of endothelial cell proliferation and regulation of phosphorylation. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rptor |
| Official Name | regulatory associated protein of MTOR, complex 1 [Source:RGD Symbol;Acc:1311784] |
| Ensembl ID | ENSRNOG00000003821 |
| Bio databases IDs | |
| Aliases | regulatory associated protein of MTOR, complex 1 |
| Synonyms | 4932417H02Rik, KOG1, Mip1, mKIAA1303, Rap, Raptor, regulatory associated protein of MTOR complex 1, regulatory associated protein of MTOR, complex 1, RGD1311784 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rptor often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein binding activity, bridging
- enzyme binding
- WD40
- protein binding
- HEAT repeats
- protein kinase activator
- HEAT repeat
- Raptor N-terminal CASPase like domain
- Raptor n-terminal conserved domain
- protein serine/threonine kinase inhibitor
- binding protein
- hinge domain
- Ribosome biogenesis protein Nsa1 and similar proteins
Pathways
Biological processes and signaling networks where the Rptor gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- HER-2 Signaling in Breast Cancer
- IL-15 Signaling
- IL-4 Signaling
- Insulin Receptor Signaling
- mTOR Signaling
- Polyamine Regulation in Colon Cancer
- Sirtuin Signaling Pathway
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- schizophrenia
- pulmonary hypertension
- insulin resistance
- coronary artery disease
- Waldenström macroglobulinemia
- acute myeloid leukemia
- astrocytosis
role in cell
- expression in
- upregulation in
- number
- phosphorylation in
- quantity
- cell viability
- morphology
- differentiation
- activation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- low-density microsomal fraction
- Nucleus
- lysosome
- Mitochondria
- cytosol
- lysosome membrane
- nucleoplasm
- stress granule
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rptor gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell size
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of glycolysis
- cellular response to amino acid stimulus
- positive regulation of cell growth
- cellular response to osmotic stress
- cellular response to leucine
- positive regulation of osteoclast differentiation
- cellular response to glucose stimulus
- cellular response to hypoxia
- positive regulation of TOR signaling cascade
- positive regulation of peptidyl-serine phosphorylation
- social behavior
- positive regulation of G1/S transition of mitotic cell cycle
- TOR signaling cascade
- cellular response to starvation
- response to DNA damage stimulus
- positive regulation of lipid biosynthetic process
- cellular response to nutrient levels
- regulation of cell growth
- negative regulation of autophagy
- regulation of autophagy
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasmic stress granule
- cytoplasm
- cytosol
- neuronal cell body
- TORC1 complex
- lysosomal membrane
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- protein kinase activator activity
- small GTPase binding
- protein binding, bridging
- 14-3-3 protein binding