Mtor Gene Summary [Rat]
Enables protein domain specific binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of muscle adaptation; and regulation of primary metabolic process. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in dendrite and neuronal cell body. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including cerebrovascular disease (multiple); obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtor |
| Official Name | mechanistic target of rapamycin kinase [Source:RGD Symbol;Acc:68371] |
| Ensembl ID | ENSRNOG00000009615 |
| Bio databases IDs | |
| Aliases | mechanistic target of rapamycin kinase |
| Synonyms | 2610315D21Rik, Flat, FRAP, FRAP1, FRAP2, FRB, mechanistic target of rapamycin kinase, mTORC1, RAFT1, RAPT1, RRAFT1, SKS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtor often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- phosphoprotein binding
- transcription factor binding
- enzyme
- protein-tyrosine kinase
- identical protein binding
- Domain of unknown function (DUF3385)
- proline rich domain
- FATC domain
- FAT domain
- FKBP12-rapamycin binding domain
- ribosome binding
- Adaptin N terminal region
- activation domain
- protein kinase binding
- autoinhibitory protein domain
- Phosphatidylinositol 3- and 4-kinase
- catalytic domain
- nucleic acid binding
- ER targeting sequence
- protein domain specific binding
- protein binding
- ribosomal DNA (rDNA) binding protein
- phosphatidic acid binding domain
- sequence-specific DNA binding
- phosphorylation site
- kinase
- kinase domain
- HEAT repeat
- Phosphoinositide 3-kinase, catalytic domain
- transcription repression domain
- binding protein
- Protein Kinases, catalytic domain
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Mtor gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Apelin Endothelial Signaling Pathway
- Autophagy
- CNTF Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- ErbB Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glioma Signaling
- HER-2 Signaling in Breast Cancer
- HIF1α Signaling
- Huntington's Disease Signaling
- JAK/Stat Signaling
- Neuregulin Signaling
- Polyamine Regulation in Colon Cancer
- Reelin Signaling in Neurons
- Role of Tissue Factor in Cancer
- Systemic Lupus Erythematosus Signaling
- Thyroid Cancer Signaling
- TR/RXR Activation
- Type II Diabetes Mellitus Signaling
- UVA-Induced MAPK Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- metastasis
- psoriasis
- skin cancer
- HIV infection
- hyperplasia
- liver neoplasia
- atopic dermatitis
- bilateral breast carcinoma
role in cell
- apoptosis
- inhibition in
- cell death
- activation
- production in
- cell viability
- formation
- activation in
- binding in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- high-density microsomal fractions
- low-density microsomal fraction
- membrane fraction
- apical ectoplasmic specialization
- glutaminergic synapse
- endomembrane system
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Plasma Membrane
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- midbody
- cytosol
- presynaptic membrane
- lysosome membrane
- nucleoplasm
- nucleoli
- nuclear envelope
- synaptic vesicles
- synaptosomes
- synapse
- sarcolemma
- late endosomes
- endolysosomes
- PML nuclear bodies
- central spindle
- mitotic spindle
- perikaryon
- dendrites
- phagosomes
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtor gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- cytoskeleton organization
- cellular response to amino acid starvation
- post-embryonic development
- protein autophosphorylation
- cardiac muscle contraction
- heart valve morphogenesis
- positive regulation of oligodendrocyte differentiation
- positive regulation of cell growth
- heart morphogenesis
- inflammatory response
- negative regulation of calcineurin-NFAT signaling cascade
- cellular response to hypoxia
- nucleus localization
- calcineurin-NFAT signaling cascade
- positive regulation of lamellipodium assembly
- negative regulation of protein localization to nucleus
- cellular response to nutrient
- anoikis
- response to nutrient
- T-helper 1 cell lineage commitment
- response to DNA damage stimulus
- regulation of actin cytoskeleton organization
- cellular response to nutrient levels
- voluntary musculoskeletal movement
- positive regulation of phosphoprotein phosphatase activity
- 'de novo' pyrimidine base biosynthetic process
- positive regulation of stress fiber assembly
- regulation of cell growth
- negative regulation of autophagy
- positive regulation of gene expression
- regulation of macroautophagy
- cardiac muscle cell development
- negative regulation of macroautophagy
- peptidyl-serine phosphorylation
- response to nutrient levels
- positive regulation of protein kinase B signaling cascade
- positive regulation of translational initiation
- multicellular organism growth
- cellular response to methionine
- regulation of cellular response to heat
- regulation of cell size
- response to amino acid stimulus
- regulation of circadian rhythm
- protein phosphorylation
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of glycolysis
- positive regulation of epithelial to mesenchymal transition
- cellular response to insulin stimulus
- cellular response to amino acid stimulus
- response to heat
- cellular response to osmotic stress
- cellular response to leucine
- regulation of osteoclast differentiation
- negative regulation of cell size
- behavioral response to pain
- positive regulation of myotube differentiation
- positive regulation of keratinocyte migration
- phosphorylation
- positive regulation of peptidyl-tyrosine phosphorylation
- macroautophagy
- regulation of action potential in neuron
- germ cell development
- lysosome organization
- oligodendrocyte differentiation
- T cell costimulation
- protein catabolic process
- energy reserve metabolic process
- TOR signaling cascade
- cellular response to starvation
- positive regulation of lipid biosynthetic process
- protein destabilization
- rhythmic process
- negative regulation of apoptotic process
- ruffle organization
- positive regulation of actin filament polymerization
- regulation of autophagic vacuole assembly
- regulation of myelination
Cellular Component
Where in the cell the gene product is active
- PML body
- phagocytic vesicle
- Golgi membrane
- mitochondrial outer membrane
- lysosomal membrane
- lysosome
- nucleoplasm
- endoplasmic reticulum membrane
- nuclear envelope
- nucleus
- dendrite
- TORC2 complex
- cytoplasm
- membrane
- cytosol
- endomembrane system
- TORC1 complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- RNA polymerase III type 3 promoter sequence-specific DNA binding
- RNA polymerase III type 2 promoter sequence-specific DNA binding
- TFIIIC-class transcription factor binding
- RNA polymerase III type 1 promoter sequence-specific DNA binding
- ATP binding
- protein binding
- ribosome binding
- phosphoprotein binding
- kinase activity