Usb1 Gene Summary [Rat]
Predicted to enable poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends. Predicted to be involved in RNA splicing and U6 snRNA 3'-end processing. Predicted to be located in intercellular bridge and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in poikiloderma with neutropenia. Orthologous to human USB1 (U6 snRNA biogenesis phosphodiesterase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usb1 |
| Official Name | U6 snRNA biogenesis phosphodiesterase 1 [Source:RGD Symbol;Acc:1305215] |
| Ensembl ID | ENSRNOG00000013216 |
| Bio databases IDs | |
| Aliases | U6 snRNA biogenesis phosphodiesterase 1 |
| Synonyms | C16orf57, hMpn1, hUsb1, HVSL1, Mpn1, PN, RGD1305215, U6 snRNA biogenesis 1, U6 snRNA biogenesis phosphodiesterase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- Uncharacterized conserved protein
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic bridges
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- snRNA 3'-end processing
- U6 snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- protein binding
- lyase activity