Ccdc115 Gene Summary [Rat]
Predicted to enable unfolded protein binding activity. Predicted to be involved in cellular response to increased oxygen levels; intracellular monoatomic cation homeostasis; and lysosomal protein catabolic process. Predicted to be located in several cellular components, including COPI-coated vesicle; endoplasmic reticulum-Golgi intermediate compartment; and lysosome. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human CCDC115 (coiled-coil domain containing 115). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ccdc115 |
| Official Name | coiled-coil domain containing 115 [Source:RGD Symbol;Acc:1304653] |
| Ensembl ID | ENSRNOG00000013234 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 115 |
| Synonyms | 2310061I09Rik, Ccp1, CDG2O, coiled-coil domain containing 115, RGD1304653 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccdc115 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 2o
- congenital disorder of glycosylation type 2
regulated by
- WAKMAR1
- black raspberry extract
- phenethyl isothiocyanate
- n-nitrosomethylbenzylamine
regulates
- iron ion
role in cell
- proliferation
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccdc115 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- vacuolar proton-transporting V-type ATPase complex assembly
- lysosomal lumen acidification
Cellular Component
Where in the cell the gene product is active
- endosome
- vacuolar proton-transporting V-type ATPase complex
- membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- COPI-coated vesicle
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- unfolded protein binding