Prkcz Gene Summary [Rat]
Enables several functions, including 14-3-3 protein binding activity; enzyme binding activity; and potassium channel regulator activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of cell communication; and regulation of protein localization. Located in several cellular components, including cell leading edge; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkcz |
| Official Name | protein kinase C, zeta [Source:RGD Symbol;Acc:3399] |
| Ensembl ID | ENSRNOG00000015480 |
| Bio databases IDs | |
| Aliases | protein kinase C, zeta |
| Synonyms | 14-3-3-zetaisoform, aPKCzeta, aPKCζ, NPKC-ZETA, NPKC-ζ, PKC2, Pkcz, PKC-ZETA, PKC-ζ, protein kinase C zeta, protein kinase C, zeta, protein kinase C ζ, protein kinase C, ζ, r14-3-3, zetaPKC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkcz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- V1 region
- Protein kinase domain
- activation loop
- PB1
- Phox and Bem1 domain
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- protein kinase C
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- activation domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- potassium channel regulator
- enzyme binding
- V0 domain
- serine/threonine kinase domain
- protein binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- pseudosubstrate domain
- zinc finger domain
Pathways
Biological processes and signaling networks where the Prkcz gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- Fc Epsilon RI Signaling
- fMLP Signaling in Neutrophils
- Glioma Signaling
- Growth Hormone Signaling
- Hepatic Cholestasis
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Insulin Receptor Signaling
- Mechanisms of Viral Exit from Host Cells
- MSP-RON Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Signaling
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- neoplasia
- metastasis
- squamous cell cancer
- liver cancer
- digestive system cancer
- Alzheimer disease
- hepatocellular carcinoma
role in cell
- expression in
- cell death
- accumulation in
- molecular cleavage in
- cell viability
- apoptosis
- proliferation
- phosphorylation in
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- apicolateral membrane
- glutaminergic synapse
- cell junction
- nuclear lipid microdomain
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- basal bodies
- endosomes
- vesicles
- intercellular junctions
- microtubule organizing centers
- cytosol
- primary cilia
- apical membrane
- nuclear envelope
- nuclear matrix
- acrosome
- axon hillock
- myelin sheath outer loop
- neurites
- synapse
- matrix vesicles
- photoreceptor inner segments
- sarcolemma
- apical cortex
- actin stress fibers
- tight junctions
- cell membrane leading edge
- axons
- postsynaptic density
- ribbon synapse
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkcz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase C signaling cascade
- positive regulation of cell proliferation
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- cellular response to insulin stimulus
- inflammatory response
- positive regulation of protein transport
- establishment or maintenance of epithelial cell apical/basal polarity
- vesicle transport along microtubule
- negative regulation of protein complex assembly
- long-term synaptic potentiation
- cell migration
- intracellular signal transduction
- positive regulation of T-helper 2 cell cytokine production
- negative regulation of peptidyl-tyrosine phosphorylation
- positive regulation of insulin receptor signaling pathway
- signal transduction
- positive regulation of T-helper 2 cell differentiation
- cell surface receptor signaling pathway
- microtubule cytoskeleton organization
- negative regulation of insulin receptor signaling pathway
- long-term memory
- positive regulation of interleukin-13 production
- positive regulation of cell-matrix adhesion
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- establishment of cell polarity
- membrane hyperpolarization
- positive regulation of excitatory postsynaptic membrane potential
- positive regulation of interleukin-10 production
- peptidyl-serine phosphorylation
- membrane depolarization
- protein localization in plasma membrane
- positive regulation of interleukin-4 production
- positive regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cell leading edge
- apical cortex
- axon hillock
- plasma membrane
- nuclear envelope
- tight junction
- occluding junction
- cell-cell junction
- extracellular vesicular exosome
- endosome
- perinuclear region of cytoplasm
- microtubule organizing center
- cytoplasm
- stress fiber
- membrane
- cell junction
- vesicle
- cytosol
- nuclear matrix
- myelin sheath abaxonal region
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- metal ion binding
- phospholipase binding
- insulin receptor substrate binding
- protein kinase activity
- protein serine/threonine kinase activity
- potassium channel regulator activity
- 14-3-3 protein binding
- protein kinase C activity