Plpbp Gene Summary [Rat]
Predicted to enable pyridoxal phosphate binding activity. Predicted to be involved in vitamin B6 metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plpbp |
| Official Name | pyridoxal phosphate binding protein [Source:RGD Symbol;Acc:1308962] |
| Ensembl ID | ENSRNOG00000013751 |
| Bio databases IDs | |
| Aliases | pyridoxal phosphate binding protein |
| Synonyms | 1700024N20RIK, 2200002F22Rik, EPEO1, EPVB6D, PROSC, pyridoxal phosphate binding protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plpbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
- enzyme
- Alanine racemase, N-terminal domain
- pyridoxal phosphate enzyme, YggS family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plpbp gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- intracellular
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding