Dmc1 Gene Summary [Rat]
Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and identical protein binding activity. Predicted to be involved in DNA recombination and chromosome organization involved in meiotic cell cycle. Predicted to act upstream of or within germ cell development; meiosis I; and ovarian follicle development. Predicted to be located in chromosome, telomeric region and lateral element. Predicted to be active in condensed nuclear chromosome and site of double-strand break. Orthologous to human DMC1 (DNA meiotic recombinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmc1 |
| Official Name | DNA meiotic recombinase 1 [Source:RGD Symbol;Acc:1307611] |
| Ensembl ID | ENSRNOG00000013807 |
| Bio databases IDs | |
| Aliases | DNA meiotic recombinase 1 |
| Synonyms | dJ199H16.1, DMC1H, DNA meiotic recombinase 1, LIM15, Mei11, sgdp |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dmc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- DNA repair and recombination protein RadA
- meiotic recombinase Dmc1
- ATP binding
- Rad51
- enzyme
- protein binding
- DNA dependent ATPase
- DNA repair protein RAD51
- identical protein binding
- DNA binding
- AAA domain
- DNA repair and recombination protein RadB
- recA bacterial DNA recombination protein
- single-stranded DNA binding
- double-stranded DNA binding
- recombinase
- KaiC
- N-terminal helicase domain of the DEAD-box helicase superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical intraepithelial neoplasia
- infertility condition
- azoospermia
- cervical cancer
role in cell
- apoptosis
- formation
- quantity
- differentiation
- development
- synapsis
- synapsis in
- lack
- meiosis
- prophase I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- chromosome
- nucleoplasm
- synaptonemal complexes
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dmc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- reciprocal meiotic recombination
- spermatid development
- spermatogenesis
- male meiosis I
- chromosome organization involved in meiosis
- strand invasion
- synapsis
- DNA recombinase assembly
- mitotic recombination
- ovarian follicle development
- meiotic cell cycle
- oocyte maturation
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- site of double-strand break
- lateral element
- chromosome
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- identical protein binding
- DNA-dependent ATPase activity
- protein binding
- recombinase activity
- double-stranded DNA binding
- single-stranded DNA binding