Nif3l1 Gene Summary [Rat]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Orthologous to human NIF3L1 (NGG1 interacting factor 3 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nif3l1 |
| Official Name | NGG1 interacting factor 3 like 1 [Source:RGD Symbol;Acc:1310329] |
| Ensembl ID | ENSRNOG00000013446 |
| Bio databases IDs | |
| Aliases | NGG1 interacting factor 3 like 1 |
| Synonyms | 1110030G24Rik, ALS2CR1, CALS-7, MDS015, NGG1 interacting factor 3 like 1, Ngg1 interacting factor 3-like 1 (S. pombe) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nif3l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NIF3 (NGG1p interacting factor 3)
- transcription factor binding
- dinuclear metal center protein, YbgI/SA1388 family
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nif3l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- neuron differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding