Psat1 Gene Summary [Rat]
Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psat1 |
| Official Name | phosphoserine aminotransferase 1 [Source:RGD Symbol;Acc:735170] |
| Ensembl ID | ENSRNOG00000013971 |
| Bio databases IDs | |
| Aliases | phosphoserine aminotransferase 1 |
| Synonyms | D8Ertd814e, EPIP, NLS2, Phosphoserine Aminotransferase, phosphoserine aminotransferase 1, PSA, PSA1, PSAT, PSATD, Similar to phosphoserine aminotransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aminotransferase class-V
- phosphoserine transaminase
- AAT_I
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colorectal cancer
- Neu-Laxova syndrome type 2
- lung adenocarcinoma
- lung adenocarcinoma formation
- non-small cell lung cancer
- lung cancer
- prostate cancer
- organismal death
role in cell
- phosphorylation in
- apoptosis
- cellular infiltration by
- expression in
- proliferation
- accumulation in
- migration
- invasiveness
- biosynthesis in
- erlotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyridoxine biosynthetic process
- L-serine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- identical protein binding
- protein binding
- O-phospho-L-serine:2-oxoglutarate aminotransferase activity