Mylk Gene Summary [Rat]
Predicted to enable enzyme binding activity; myosin light chain kinase activity; and scaffold protein binding activity. Involved in regulation of synaptic vesicle endocytosis. Is active in synapse. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; coronary artery disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mylk |
| Official Name | myosin light chain kinase [Source:RGD Symbol;Acc:1310915] |
| Ensembl ID | ENSRNOG00000002215 |
| Bio databases IDs | |
| Aliases | myosin light chain kinase |
| Synonyms | 130 KDA MLCK, 9530072E15RIK, A930019C19RIK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MMIHS, MMIHS1, MSTP083, MYLK1, MYLK-L, Mylk predicted, myosin light chain kinase, myosin, light polypeptide kinase, smMLCK, TELOKIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mylk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin light chain kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- immunoglobulin domain
- calmodulin binding domain
- Immunoglobulin I-set domain
- enzyme binding
- protein binding
- Fibronectin type 3 domain
- motor domain
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- FN3
- Immunoglobulin like
- Unstructured linker between I-set domains 2 and 3 on MYLCK
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Mylk gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Adrenomedullin signaling pathway
- Apelin Cardiomyocyte Signaling Pathway
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- G-Protein Coupled Receptor Signaling
- Integrin Signaling
- PAK Signaling
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometrial cancer
- preeclampsia
- experimental autoimmune encephalomyelitis
- visceral myopathy type 1
- familial thoracic aortic aneurysm type 7
- colon carcinoma
- colon epithelial cancer
- prostate cancer
- bladder cancer
role in cell
- expression in
- proliferation
- apoptosis
- binding in
- activation in
- production in
- recruitment in
- formation
- formation in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perijunctional region
- actin cytoskeleton
- Plasma Membrane
- intercellular junctions
- cytosol
- synapse
- myosin filaments
- actin stress fibers
- cleavage furrow
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mylk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bleb assembly
- positive regulation of wound healing
- cellular hypotonic response
- smooth muscle contraction
- positive regulation of calcium ion transport
- protein phosphorylation
- tonic smooth muscle contraction
- aorta smooth muscle tissue morphogenesis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cleavage furrow
- stress fiber
- actin cytoskeleton
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- actin binding
- metal ion binding
- myosin light chain kinase activity