Rab32 Gene Summary [Rat]
The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Rab32 |
| Official Name | RAB32, member RAS oncogene family [Source:RGD Symbol;Acc:1559997] |
| Ensembl ID | ENSRNOG00000014258 |
| Bio databases IDs | |
| Aliases | RAB32, member RAS oncogene family |
| Synonyms | 2810011A17RIK, PARK26, RAB32, member RAS oncogene family, RGD1559997 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab32 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- alpha helix
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- binding protein
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- septic shock
- severe acute respiratory syndrome
role in cell
- cell death
- cell viability
- apoptosis
- growth
- formation
- phosphorylation in
- maturation
- accumulation
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- membrane compartment
- granules
- cytosol
- mitochondria-associated membranes
- mitochondrial outer membrane
- early endosomes
- melanosomes
- rough endoplasmatic reticulum
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab32 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- melanosome organization
- vesicle-mediated transport
- protein localization in membrane
- endosome to melanosome transport
- antigen processing and presentation
- phagosome maturation
- intracellular protein transport
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- phagocytic vesicle
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
- mitochondrial outer membrane
- early endosome
- trans-Golgi network
- early endosome lumen
- melanosome
- mitochondrion
- membrane
- endomembrane system
- phagocytic vesicle membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- AP-1 adaptor complex binding
- AP-3 adaptor complex binding
- protein binding
- GTPase activity
- GTP-dependent protein binding
- AP-2 adaptor complex binding