Dnm1l Gene Summary [Rat]
Enables several functions, including BH2 domain binding activity; identical protein binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including positive regulation of cellular component organization; response to hypoxia; and synaptic vesicle recycling. Located in several cellular components, including Golgi membrane; clathrin-coated pit; and perinuclear region of cytoplasm. Is active in presynaptic endocytic zone membrane and synaptic vesicle membrane. Biomarker of chronic kidney disease; dental fluorosis; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnm1l |
| Official Name | dynamin 1-like [Source:RGD Symbol;Acc:620416] |
| Ensembl ID | ENSRNOG00000001813 |
| Bio databases IDs | |
| Aliases | dynamin 1-like |
| Synonyms | 6330417M19Rik, DLP1, Dnml1, DNMLP1, DRP1, DVLP, DYMPLE, dynamin 1-like, Dynamin-related protein 1, EMPF, EMPF1, HDYNIV, OPA5, python |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnm1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynamin GTPase effector domain
- ubiquitin protein ligase binding
- GTP-dependent protein binding
- protein kinase binding
- enzyme binding
- clathrin binding
- GTPase
- dynamin GTPase
- protein domain specific binding
- enzyme
- protein binding
- identical protein binding
- Dynamin family
- binding protein
- GTPase domain
- Dynamin central region
- LXVP motif
- protein homodimerization
- Pka phosphorylation site
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Dnm1l gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- epithelial cancer
- epithelial neoplasia
- cancer
- chronic obstructive pulmonary disease
- adenoma formation
- amyotrophic lateral sclerosis
- bleeding
- lethal encephalopathy
- liver cancer
role in cell
- expression in
- growth
- cell viability
- phosphorylation in
- number
- production in
- activation in
- oxidation in
- aggregation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- mitochondrial fraction
- mitochondrial fission sites
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- reticular fibers
- perinuclear region
- membrane surface
- cellular membrane
- cell cortex
- Nucleus
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- microtubule bundles
- cytosol
- endoplasmic reticulum membrane
- synaptic membrane
- Golgi membrane
- mitochondrial membrane
- mitochondrial outer membrane
- neurites
- cytoplasmic vesicles
- secretory vesicles
- peroxisomes
- rough microsomes
- brush border
- clathrin-coated pits
- perikaryon
- peroxisomal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnm1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart contraction
- protein localization in mitochondrion
- necroptosis
- calcium ion transport
- positive regulation of protein secretion
- positive regulation of intrinsic apoptotic signaling pathway
- peroxisome fission
- regulation of peroxisome organization
- membrane fusion
- membrane fission involved in mitochondrial fission
- macromolecular complex assembly
- positive regulation of neutrophil chemotaxis
- positive regulation of release of cytochrome c from mitochondria
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of mitochondrial fission
- endocytosis
- endoplasmic reticulum organization
- mitochondrion organization
- mitochondrial fission
- rhythmic process
- intracellular distribution of mitochondria
- positive regulation of apoptotic process
- release of cytochrome c from mitochondria
- regulation of gene expression
- regulation of mitochondrion organization
- protein oligomerization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- mitochondrial outer membrane
- microtubule
- endoplasmic reticulum membrane
- peroxisome
- perinuclear region of cytoplasm
- brush border
- cytoplasm
- intracellular membrane-bounded organelle
- coated pit
- mitochondrion
- membrane
- cytosol
- macromolecular complex
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- protein binding
- GTPase activity
- GTPase activator activity
- small GTPase binding
- lipid binding
- microtubule binding
- GTP-dependent protein binding