Dbx1 Gene Summary [Rat]
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation in spinal cord and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within ventral spinal cord interneuron specification. Predicted to be located in nucleus. Orthologous to human DBX1 (developing brain homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbx1 |
| Official Name | developing brain homeobox 1 [Source:RGD Symbol;Acc:1308896] |
| Ensembl ID | ENSRNOG00000014706 |
| Bio databases IDs | |
| Aliases | developing brain homeobox 1 |
| Synonyms | Dbx, developing brain homeobox 1, HLX1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dbx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Eh1 motif
- protein binding
- homeodomain
Pathways
Biological processes and signaling networks where the Dbx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dbx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation in spinal cord
- regulation of transcription from RNA polymerase II promoter
- ventral spinal cord interneuron specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity