Ppie Gene Summary [Rat]
Predicted to enable RNA binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in gene expression; positive regulation of viral genome replication; and regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppie |
| Official Name | peptidylprolyl isomerase E [Source:RGD Symbol;Acc:1311411] |
| Ensembl ID | ENSRNOG00000014762 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase E |
| Synonyms | 2010010D16Rik, Ab1-210, Cyclophilin E, CYP-33, CypE, peptidylprolyl isomerase E, peptidylprolyl isomerase E (cyclophilin E) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppie often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- peptidylprolyl isomerase
- RNA recognition motif
- mRNA binding
- cyclophilin
- cyclosporin A binding
- poly(A) binding protein
- enzyme
- Occluded RNA-recognition motif
- protein binding
- RNA binding
- spacer domain
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppie gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- protein peptidyl-prolyl isomerization
- protein folding
- positive regulation of viral genome replication
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- U2-type catalytic step 2 spliceosome
- cytosol
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- RNA binding
- poly(A) RNA binding
- mRNA binding