Xab2 Gene Summary [Rat]
Involved in cerebral cortex development. Predicted to be located in nucleoplasm. Predicted to be part of Prp19 complex; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Orthologous to human XAB2 (XPA binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xab2 |
| Official Name | XPA binding protein 2 [Source:RGD Symbol;Acc:621217] |
| Ensembl ID | ENSRNOG00000000988 |
| Bio databases IDs | |
| Aliases | XPA binding protein 2 |
| Synonyms | 0610041O14RIK, ATH55, HCNP, HCRN, KIAA1177, NTC90, SYF1, XPA binding protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Xab2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- synthesis in
- cell death
- formation
- splicing by
- formation in
- molecular cleavage in
- replication in
- damage in
- alternative splicing in
- reverse transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- intracellular membrane-bounded organelle
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Xab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- blastocyst development
- transcription-coupled nucleotide-excision repair
- generation of catalytic spliceosome for first transesterification step
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- post-mRNA release spliceosomal complex
- intracellular membrane-bounded organelle
- membrane
- U2-type catalytic step 2 spliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding