PPIE Gene Summary [Human]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | PPIE |
| Official Name | peptidylprolyl isomerase E [Source:HGNC Symbol;Acc:HGNC:9258] |
| Ensembl ID | ENSG00000084072 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase E, peptidyl-prolyl cis-trans isomerase E, cyclophilin 33, cyclophilin E, PPIase E, rotamase E, peptidylprolyl isomerase E, isoform 1 |
| Synonyms | 2010010D16Rik, Ab1-210, Cyclophilin E, CYP-33, CypE, peptidylprolyl isomerase E, peptidylprolyl isomerase E (cyclophilin E) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- peptidylprolyl isomerase
- RNA recognition motif
- mRNA binding
- cyclophilin
- cyclosporin A binding
- poly(A) binding protein
- enzyme
- Occluded RNA-recognition motif
- protein binding
- RNA binding
- spacer domain
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- protein peptidyl-prolyl isomerization
- protein folding
- positive regulation of viral genome replication
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- U2-type catalytic step 2 spliceosome
- cytosol
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- RNA binding
- poly(A) RNA binding
- mRNA binding