Atp5mc2 Gene Summary [Rat]
Enables ligand-gated channel activity. Involved in pore complex assembly; response to 3,3',5-triiodo-L-thyronine; and response to ethanol. Part of cation channel complex. Human ortholog(s) of this gene implicated in renal cell carcinoma and urinary bladder cancer. Orthologous to human ATP5MC2 (ATP synthase membrane subunit c locus 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5mc2 |
| Official Name | ATP synthase membrane subunit c locus 2 [Source:RGD Symbol;Acc:620051] |
| Ensembl ID | ENSRNOG00000015320 |
| Bio databases IDs | |
| Aliases | ATP synthase membrane subunit c locus 2 |
| Synonyms | 1810041M08Rik, ATP5A, ATP5G2, Atp Synthase Lipid-Binding Protein P2 Precursor, ATP synthase membrane subunit c locus 2, LOC100504871 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5mc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP synthase subunit C
- PRK13469
- adenosine-tetraphosphatase
- channel/pore class transporter
- ATP synthase, membrane-bound Fo/Vo/Ao complexes, subunit c
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Atp5mc2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5mc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
- mitochondrial outer membrane
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transmembrane transporter activity
- lipid binding