Npr3 Gene Summary [Rat]
Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and positive regulation of nitric-oxide synthase activity. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npr3 |
| Official Name | natriuretic peptide receptor 3 [Source:RGD Symbol;Acc:3196] |
| Ensembl ID | ENSRNOG00000019184 |
| Bio databases IDs | |
| Aliases | natriuretic peptide receptor 3 |
| Synonyms | ANP-C, ANP-CR, ANPR-C, B430320C24RIK, BOMOS, C5orf23, EF-2, FLJ14054, GUCY2B, lgj, Natriuretic peptide clearance receptor, natriuretic peptide receptor 3, Natriuretic Peptide Receptor C, NPR-C, stri |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- natriuretic peptide receptor
- peptide binding
- Receptor family ligand binding region
- hormone binding
- protein binding
- identical protein binding
- polypeptide hormone binding
- binding protein
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- protein homodimerization
Pathways
Biological processes and signaling networks where the Npr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- irritable bowel syndrome characterized by constipation
- congestive heart failure
- cardiorenal syndrome
- chronic idiopathic constipation
- cardiomyopathy
- kidney disease
- hypertension
- pulmonary hypertension
- coronary artery disease
role in cell
- expression in
- apoptosis
- proliferation
- size
- phosphorylation in
- production in
- formation in
- abnormal morphology
- number
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- pH resistant lipid raft fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast proliferation
- blood vessel remodeling
- response to ischemia
- skeletal system development
- positive regulation of nitric-oxide synthase activity
- G-protein coupled receptor signaling pathway
- angiogenesis
- signal transduction
- regulation of blood pressure
- positive regulation of urine volume
- regulation of osteoblast proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chloride ion binding
- G-protein coupled peptide receptor activity
- protein binding
- protein homodimerization activity
- hormone binding
- peptide hormone binding
- peptide binding
- natriuretic peptide receptor activity