Rhcg Gene Summary [Rat]
Enables ammonium channel activity. Involved in ammonium transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Biomarker of hypokalemia; kidney failure; and metabolic acidosis. Orthologous to human RHCG (Rh family C glycoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhcg |
| Official Name | Rh family, C glycoprotein [Source:RGD Symbol;Acc:727859] |
| Ensembl ID | ENSRNOG00000015526 |
| Bio databases IDs | |
| Aliases | Rh family, C glycoprotein |
| Synonyms | BB065800, C15ORF6, PDRC2, Rhesus blood group-associated C glycoprotein, Rh family C glycoprotein, Rh family, C glycoprotein, RHGK, SLC42A3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rhcg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ankyrin binding
- protein binding
- identical protein binding
- ammonium transporter
- transporter
- Ammonium Transporter Family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- organismal death
- acute myeloid leukemia
- metastasis
- dental caries
- renal tubular acidosis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- insomnia
regulates
- bicarbonate
- ammonium
- K+
- SLC12A1
role in cell
- proliferation
- migration
- permeability
- pH
- ion homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- apical membrane
- basolateral membrane
- basal membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rhcg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- ammonium transmembrane transport
- homeostatic process
- amine transport
- ammonia homeostasis
- carbon dioxide transmembrane transport
- transepithelial ammonium transport
- cellular ion homeostasis
- regulation of pH
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasmic vesicle
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ammonium transmembrane transporter activity
- identical protein binding
- protein binding
- ankyrin binding
- carbon dioxide transmembrane transporter activity