Scarb2 Gene Summary [Rat]
Predicted to enable several functions, including cholesterol binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in positive regulation of neuron projection development. Predicted to be located in endocytic vesicle membrane and lysosomal lumen. Predicted to be active in lysosomal membrane and plasma membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scarb2 |
| Official Name | scavenger receptor class B, member 2 [Source:RGD Symbol;Acc:621882] |
| Ensembl ID | ENSRNOG00000002225 |
| Bio databases IDs | |
| Aliases | scavenger receptor class B, member 2 |
| Synonyms | 9330185J12RIK, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMP II, MLGP85, scavenger receptor class B member 2, scavenger receptor class B, member 2, SR-BII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scarb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- cholesterol binding
- cargo receptor activity
- enzyme binding
- protein binding
- binding protein
- scavenger receptor
- lumenal domain
- protein homodimerization
- chaperone binding
- cytosolic tail domain
- CD36 family
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- cardiomyopathy
- organismal death
- Huntington disease
- REM sleep behavior disorder
- progressive myoclonic epilepsy type 4 with renal failure
- neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- transactivation in
- growth
- fusion
- apoptosis
- accumulation in
- cell viability
- clonogenicity
- transformation
- degradation
- tumorsphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- endocytic vesicle membrane
- Cytoplasm
- intracellular space
- cellular membrane
- endosomes
- lysosome
- endoplasmic reticulum membrane
- Golgi membrane
- trans Golgi network
- lysosome membrane
- lysosomal compartment
- endosomal membrane
- intercalated disks
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scarb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- sensory perception of sound
- regulation of carbohydrate catabolic process
- aminophospholipid transport
- regulation of glucosylceramide catabolic process
- positive regulation of neuron projection development
- protein targeting to lysosome
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- lysosomal lumen
- Golgi membrane
- plasma membrane
- lysosomal membrane
- endoplasmic reticulum membrane
- late endosome membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- endosome membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- transmembrane signaling receptor activity
- protein homodimerization activity
- protein binding
- cholesterol binding
- cargo receptor activity
- chaperone binding
- scavenger receptor activity
- viral receptor activity
- phosphatidylcholine binding
- enzyme binding