Slc9a2 Gene Summary [Rat]
Enables sodium:proton antiporter activity. Involved in sodium ion transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC9A2 (solute carrier family 9 member A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc9a2 |
| Official Name | solute carrier family 9 member A2 [Source:RGD Symbol;Acc:3719] |
| Ensembl ID | ENSRNOG00000015567 |
| Bio databases IDs | |
| Aliases | solute carrier family 9 member A2 |
| Synonyms | 2210416H12RIK, 4932415O19, 4932415O19Rik, AV333884, NHE-2, solute carrier family 9 member A2, solute carrier family 9 (sodium/hydrogen exchanger), member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc9a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
- Sodium/hydrogen exchanger family
- Na+/H+ antiporter, bacterial form
- sodium/hydrogen exchanger 3
- proline rich domain
- transporter
- sodium:hydrogen antiporter
Pathways
Biological processes and signaling networks where the Slc9a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- endometriosis
- allergic asthma
- hypochlorhydria
regulates
- Na+
- ion
role in cell
- differentiation
- abnormal morphology
- intracellular pH
- pH
- sodium/hydrogen exchange
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- apical membrane
- basal membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc9a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- regulation of intracellular pH
- ion transport
- potassium ion transmembrane transport
- protein localization
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- potassium:hydrogen antiporter activity
- sodium:hydrogen antiporter activity