Plpp5 Gene Summary [Rat]

Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
Plpp5
Official Name
phospholipid phosphatase 5 [Source:RGD Symbol;Acc:1591734]
Ensembl ID
ENSRNOG00000015568
Bio databases IDs NCBI: 680466 Ensembl: ENSRNOG00000015568
Aliases phospholipid phosphatase 5
Synonyms 1810019D05Rik, 2310022A04Rik, DPPL1, HTPAP, LOC683534, phospholipid phosphatase 5, Ppapdc1, PPAPDC1B
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plpp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • diacylglycerol pyrophosphate phosphatase
  • Acid phosphatase homologues
  • PAP2 superfamily
  • phosphatidate phosphatase
  • enzyme
  • protein binding
  • PAP2_like

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hepatocellular carcinoma
  • liver cancer
  • epithelial cancer
  • HER2 negative hormone receptor negative breast cancer
  • breast cancer
regulated by
  • lipopolysaccharide
  • TCF3
  • TCF4
  • birinapant
  • K562 cells
  • TRIM38
  • OSW-1
  • ELL2
regulates
  • phospholipid

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Plpp5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • phospholipid dephosphorylation
  • phospholipid metabolic process

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • phosphatidate phosphatase activity
  • protein binding
  • diacylglycerol diphosphate phosphatase activity