Tcf4 Gene Summary [Rat]
Enables bHLH transcription factor binding activity and double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF7L2 complex. Predicted to be active in chromatin. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Lynch syndrome; and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf4 |
| Official Name | transcription factor 4 [Source:RGD Symbol;Acc:69271] |
| Ensembl ID | ENSRNOG00000012405 |
| Bio databases IDs | |
| Aliases | transcription factor 4 |
| Synonyms | 5730422P05RIK, ASP-I2, bHLHb19, CDG2T, E2-2, E2.2, FCD2, FECD3, ITF-2, ME2, MITF-2A, MITF-2B, PTHS, SEF-2, SEF2-1, SEF2-1A, SEF2-1D, TFE, transcription factor 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tcf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- beta-catenin binding
- transcription co-repressor
- basic Helix Loop Helix (bHLH) domain superfamily
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Tcf4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Basal Cell Carcinoma Signaling
- Colorectal Cancer Metastasis Signaling
- DNA Methylation and Transcriptional Repression Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Opioid Signaling Pathway
- Ovarian Cancer Signaling
- PEDF Signaling
- Polyamine Regulation in Colon Cancer
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Thyroid Cancer Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- insomnia
- schizophrenia
- Fuchs endothelial dystrophy
- Pitt-Hopkins syndrome
- obesity
- developmental disorder
role in cell
- proliferation
- hypertrophy
- differentiation
- quantity
- growth
- expression in
- apoptosis
- invasion
- development
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tcf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein-DNA complex assembly
- positive regulation of transcription, DNA-dependent
- nervous system development
- cell differentiation
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- beta-catenin-TCF7L2 complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- TFIIB-class transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding