Wdr34 Gene Summary [Rat]
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium assembly and intraciliary retrograde transport. Predicted to be located in several cellular components, including filopodium; microtubule organizing center; and nucleus. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr34 |
| Official Name | WD repeat domain 34 [Source:RGD Symbol;Acc:1359465] |
| Ensembl ID | ENSRNOG00000015636 |
| Bio databases IDs | |
| Aliases | WD repeat domain 34 |
| Synonyms | 3200002I06Rik, bA216B9.3, CFAP133, DIC5, dynein 2 intermediate chain 2, FAP133, SRTD11, WDR34 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- dynein light chain binding
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Wdr34 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- digenic short rib thoracic dysplasia 3/6 with polydactyly
- short-rib thoracic dysplasia type 11
- short-rib thoracic dysplasia type 11 without polydactyly
- growth failure
- Jeune syndrome
- microphthalmia
- exencephaly
- polydactyly
- spina bifida
regulated by
regulates
- NFkB (complex)
role in cell
- activation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary tip
- cilia
- basal bodies
- centrosome
- centriole
- axonemes
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear envelope
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar transport
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic dynein complex
- centrosome
- microtubule-based flagellar cytoplasm
- cytoplasm
- cilium basal body
- centriole
- cilium
- filopodium
- cytosol
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein heavy chain binding
- dynein light chain binding