Traf6 Gene Summary [Rat]
Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and ubiquitin-ubiquitin ligase activity. Involved in several processes, including interleukin-1-mediated signaling pathway; regulation protein catabolic process at postsynapse; and response to ischemia. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human TRAF6 (TNF receptor associated factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf6 |
| Official Name | TNF receptor associated factor 6 [Source:RGD Symbol;Acc:1306853] |
| Ensembl ID | ENSRNOG00000004639 |
| Bio databases IDs | |
| Aliases | TNF receptor associated factor 6 |
| Synonyms | 2310003F17Rik, C630032O20Rik, LOC100042930, LOC100048242, MGC:3310, RNF85, TNF receptor-associated factor 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Traf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- coiled-coil domain
- enzyme
- identical protein binding
- TRAF-type zinc finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- TRAF-like zinc-finger
- CART domain
- protein kinase binding
- MATH
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- TRAF-N subdomain
- enzyme binding
- histone deacetylase binding
- Ring finger domain
- protein binding
- TRAF domain
- TNF receptor-associated factor 6 zinc finger 2
- RING-type zinc-finger
- Modified RING finger domain
- ubiquitin-protein transferase activity
- zinc finger domain
- TRAF-C subdomain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Traf6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- April Mediated Signaling
- Autophagy
- B Cell Activating Factor Signaling
- CD40 Signaling
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- IL-1 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-6 Signaling
- iNOS Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- Lymphotoxin β Receptor Signaling
- NF-κB Signaling
- p38 MAPK Signaling
- PPARα/RXRα Activation
- RANK Signaling in Osteoclasts
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- fibrosis
- glioma formation
- glioma
- dextran sodium sulfate-induced colitis
- lipopolysaccharide-induced lung injury
- osteopetrosis
- Churg-Strauss syndrome
- exencephaly
- neurological deficiency
role in cell
- expression in
- proliferation
- phosphorylation in
- activation in
- tyrosine phosphorylation in
- number
- migration
- production in
- cell death
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- lipid droplets
- cytosol
- cytoplasmic face of plasma membrane
- endosomal membrane
- nucleoplasm
- nuclear envelope
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Traf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- cytoplasmic pattern recognition receptor signaling pathway
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of transcription regulatory region DNA binding
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- bone resorption
- ossification
- regulation of immunoglobulin production
- positive regulation of protein ubiquitination
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- NIK/NF-kappaB cascade
- regulation of apoptotic process
- positive regulation of T cell proliferation
- response to DNA damage stimulus
- tumor necrosis factor-mediated signaling pathway
- positive regulation of T cell cytokine production
- response to interleukin-1
- toll-like receptor 3 signaling pathway
- lipopolysaccharide-mediated signaling pathway
- positive regulation of interleukin-6 production
- positive regulation of lipopolysaccharide-mediated signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
- Fc-epsilon receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of I-kappaB kinase/NF-kappaB cascade
- odontogenesis of dentin-containing tooth
- positive regulation of transcription from RNA polymerase II promoter
- stimulatory C-type lectin receptor signaling pathway
- autophagic vacuole assembly
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoclast differentiation
- neural tube closure
- myeloid dendritic cell differentiation
- activation of protein kinase activity
- T cell receptor signaling pathway
- positive regulation of interleukin-2 production
- protein autoubiquitination
- protein polyubiquitination
- T-helper 1 type immune response
- I-kappaB kinase/NF-kappaB cascade
- osteoclast differentiation
- positive regulation of interleukin-12 production
- cellular response to lipopolysaccharide
- innate immune response
- protein K63-linked ubiquitination
- cellular response to cytokine stimulus
- interleukin-1-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- internal side of plasma membrane
- lipid particle
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- cytosol
- extrinsic to internal side of plasma membrane
- endosome membrane
- macromolecular complex
- CD40 receptor complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- zinc ion binding
- ubiquitin conjugating enzyme binding
- protein binding
- histone deacetylase binding
- ubiquitin-ubiquitin ligase activity
- tumor necrosis factor receptor binding
- protein kinase B binding