LOC100909857 Gene Summary [Rat]
Enables cytidine deaminase activity. Involved in cellular response to external biotic stimulus; cytidine deamination; and response to cycloheximide. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC100909857 |
| Official Name | cytidine deaminase-like [Source:RGD Symbol;Acc:6501229] |
| Ensembl ID | ENSRNOG00000015677 |
| Bio databases IDs | |
| Aliases | cytidine deaminase-like |
| Synonyms | 2210401N16Rik, CDD, cytidine deaminase, LOC100909857 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100909857 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytidine_deaminase-like
- Cytidine and deoxycytidylate deaminase zinc-binding region
- nuclear localization sequence
- deaminase
- enzyme
- protein binding
- identical protein binding
- binding protein
- deoxycytidine deaminase
- zinc ion binding
- cytidine deaminase, homotetrameric
- cytidine deaminase
- active site
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- alpha-hydroxyglutarate
- uridine
- fumaric acid
- succinic acid
- enzyme
- cytosine
- gemcitabine triphosphate
- gemcitabine
- malic acid
- deoxycytidine
disease
- liver cancer
- epithelial cancer
- neoplasia
- myelodysplastic syndrome
- secondary refractory anemia
- acute myeloid leukemia
- secondary refractory anemia with excess blasts in transformation
- uterine serous papillary cancer
- neutropenia
- myelodysplastic syndrome with ring sideroblasts
phenotypes
- non-small cell lung carcinoma
role in cell
- growth
- cell death
- function
- colony formation
- excision repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- organelle lumens
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100909857 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytosine metabolic process
- negative regulation of nucleotide metabolic process
- negative regulation of cell growth
- response to cycloheximide
- cytidine deamination
- cell surface receptor signaling pathway
- cellular response to external biotic stimulus
- pyrimidine-containing compound salvage
- UMP salvage
Cellular Component
Where in the cell the gene product is active
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein homodimerization activity
- protein binding
- cytidine deaminase activity
- nucleoside binding