Muc1 Gene Summary [Rat]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to retinoic acid; female pregnancy; and response to hypoxia. Located in apical plasma membrane. Used to study allergic rhinitis. Biomarker of allergic rhinitis; cholangiocarcinoma; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant tubulointerstitial kidney disease; biliary tract benign neoplasm; dry eye syndrome; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Muc1 |
| Official Name | mucin 1, cell surface associated [Source:RGD Symbol;Acc:3122] |
| Ensembl ID | ENSRNOG00000020539 |
| Bio databases IDs | |
| Aliases | mucin 1, cell surface associated |
| Synonyms | ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, EMA, EMA1, Episialin, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, mucin, Mucin1, mucin 1, cell surface associated, Mucin 1 (episialin), Mucin-1 subunit beta, Mucin-1 subunit β, mucin 1, transmembrane, PANCREATIC MUCIN, PEM, PEMT, PUM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Muc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- nucleic acid binding
- ectodomain
- SEA domain
- transcription cofactor
- p53 binding
- protein binding
- sequence-specific DNA binding
- tandem repeat
- serine-rich region
- cytoplasmic domain
- double-stranded DNA binding
- transmembrane domain
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Muc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- cancer
- osteoarthritis
- digestive system cancer
- abdominal cancer
- metastasis
- lung adenocarcinoma formation
role in cell
- phosphorylation in
- expression in
- invasion by
- transcription in
- growth
- cell death
- apoptosis
- activation in
- quantity
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Golgi lumen
- extracellular vesicles
- Cytoplasm
- cell surface
- Extracellular Space
- apical compartment
- membrane surface
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- Mitochondria
- cell-cell contacts
- cytosol
- apical cell surfaces
- apical membrane
- perinuclear space
- peripheral vesicles
- chromatin
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Muc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell adhesion mediated by integrin
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of transcription by competitive promoter binding
- DNA damage response, signal transduction by p53 class mediator
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- vesicle
- Golgi lumen
- chromatin
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- transcription cofactor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding