F2 Gene Summary [Rat]
Predicted to enable several functions, including heparin binding activity; lipopolysaccharide binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to mechanical stimulus; response to thyrotropin-releasing hormone; and response to thyroxine. Located in collagen-containing extracellular matrix and extracellular space. Used to study several diseases, including atherosclerosis; end stage renal disease; hyperhomocysteinemia; obesity; and thrombophilia (multiple). Biomarker of bacterial pneumonia; brain edema; calcium oxalate nephrolithiasis; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including appendicitis; artery disease (multiple); autoimmune disease (multiple); hemophilia (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | F2 |
| Official Name | coagulation factor II [Source:RGD Symbol;Acc:61996] |
| Ensembl ID | ENSRNOG00000016325 |
| Bio databases IDs | |
| Aliases | coagulation factor II |
| Synonyms | Cf-2, Coagulation factor 2, Coagulation Factor II, coagulation factor II, thrombin, DCP, factor II, FII, Meizothrombin Des-Fragment 1, Prothrombin, PT, rh thrombin, RPRGL2, THPH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Trypsin-like serine protease
- peptidase
- heparin binding domain
- enzyme
- growth factor
- trypsin
- non-catalytic domain
- thrombin
- fibrinogen binding domain
- Factor Xa cleavage site
- activation domain
- signaling receptor activity
- anion binding exosite
- Tryp_SPc
- catalytic domain
- protein binding
- receptor binding
- lipopolysaccharide binding
- endopeptidase
- serine endopeptidase
- active site
- receptor agonist activity
- Thrombin light chain
- Thrombomodulin binding domain
- heparin binding
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Pathways
Biological processes and signaling networks where the F2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- hyperalgesia
- infection
- non-small cell lung cancer
- aortic stenosis
- ischemic cardiomyopathy
- acute respiratory distress syndrome
- hepatocellular carcinoma
- Reye syndrome
role in cell
- proliferation
- binding
- apoptosis
- activation in
- production in
- growth
- release in
- morphology
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Golgi lumen
- Cytoplasm
- cell surface
- Plasma Membrane
- vesicles
- cytosol
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of blood coagulation
- regulation of blood coagulation
- positive regulation of cell proliferation
- response to wounding
- negative regulation of astrocyte differentiation
- negative regulation of proteolysis
- negative regulation of cytokine production involved in inflammatory response
- blood coagulation
- fibrinolysis
- positive regulation of cell growth
- positive regulation of collagen biosynthetic process
- positive regulation of insulin secretion
- neutrophil mediated killing of gram-negative bacterium
- platelet activation
- positive regulation of reactive oxygen species metabolic process
- positive regulation of lipid kinase activity
- positive regulation of protein localization to nucleus
- negative regulation of fibrinolysis
- G-protein coupled receptor signaling pathway
- cytosolic calcium ion homeostasis
- cell surface receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- acute-phase response
- positive regulation of JAK-STAT cascade
- positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of protein phosphorylation
- proteolysis
- cytolysis by host of symbiont cells
- negative regulation of platelet activation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- external side of plasma membrane
- extracellular region
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- thrombospondin receptor activity
- growth factor activity
- protein binding
- calcium ion binding
- serine-type endopeptidase activity
- heparin binding
- receptor binding
- lipopolysaccharide binding