Serpind1 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpind1 |
| Official Name | serpin family D member 1 [Source:RGD Symbol;Acc:619854] |
| Ensembl ID | ENSRNOG00000001865 |
| Bio databases IDs | |
| Aliases | serpin family D member 1 |
| Synonyms | D22S673, HC2, HCF2, HC-II, HLS2, LS2, rls2var1, serine (or cysteine) peptidase inhibitor, clade D, member 1, serpin family D member 1, THPH10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpind1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- WYF domain
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Serpind1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombosis
- COVID-19
- venous stasis syndrome
- heparin cofactor II deficiency
- global developmental delay with intellectual disability
- diabetic nephropathy
- thrombophilia due to heparin cofactor II deficiency
- bleeding
- endothelial dysfunction
- papilloma
role in cell
- phosphorylation in
- quantity
- aggregation
- proliferation
- migration
- tubulation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpind1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- negative regulation of endopeptidase activity
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- heparin binding