F10 Gene Summary [Rat]
Predicted to enable phospholipid binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation and positive regulation of TOR signaling. Predicted to be active in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Orthologous to human F10 (coagulation factor X). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | F10 |
| Official Name | coagulation factor X [Source:RGD Symbol;Acc:61850] |
| Ensembl ID | ENSRNOG00000033444 |
| Bio databases IDs | |
| Aliases | coagulation factor X |
| Synonyms | AI194738, Cf10, Coagulation factor 10, coagulation factor X, Factor X, FX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Trypsin-like serine protease
- Tryp_SPc
- catalytic domain
- peptidase
- Human growth factor-like EGF
- protein binding
- EGF-like domain
- EGF_CA
- protease domain
- trypsin
- serine endopeptidase
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- Coagulation Factor Xa inhibitory site
- coagulation factor Xa
Pathways
Biological processes and signaling networks where the F10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- anemia
- lymphoma
- myelodysplastic syndrome
- chronic myeloproliferative disorder
- plasma cell myeloma
- leukemia
- shock response
- dengue hemorrhagic fever
- preterm birth
role in cell
- expression in
- phosphorylation in
- migration
- activation
- activation in
- uptake in
- chemotaxis
- adhesion
- activity
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- blood coagulation
- positive regulation of TOR signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- external side of plasma membrane
- extracellular region
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- serine-type endopeptidase activity
- phospholipid binding