Uox Gene Summary [Rat]
Enables urate oxidase activity. Involved in urate catabolic process. Located in peroxisome. Used to study hyperuricemia. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uox |
| Official Name | urate oxidase [Source:RGD Symbol;Acc:621369] |
| Ensembl ID | ENSRNOG00000016339 |
| Bio databases IDs | |
| Aliases | urate oxidase |
| Synonyms | UOX-2, Urate oxidase, Uri, Uri2, URICASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TFold
- urate oxidase
- enzyme
- Uricase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- polyuria
- hydronephrosis
- fibrosis
- crystalluria
- hyperplasia
- interstitial nephritis
- insulin resistance
role in cell
- quantity
- accumulation in
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- membrane fraction
- peroxisomal matrix
- microbody
- cytosol
- Golgi membrane
- peroxisomes