Nr1i2 Gene Summary [Rat]
Enables nuclear receptor activity. Predicted to be involved in several processes, including cellular response to molecule of bacterial origin; cellular response to type I interferon; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of gene expression. Predicted to be located in intermediate filament cytoskeleton and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Biomarker of cholestasis and epilepsy. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr1i2 |
| Official Name | nuclear receptor subfamily 1, group I, member 2 [Source:RGD Symbol;Acc:69057] |
| Ensembl ID | ENSRNOG00000002906 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 1, group I, member 2 |
| Synonyms | BXR, mPXR, nuclear receptor subfamily 1 group I member 2, nuclear receptor subfamily 1, group I, member 2, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR1, PXR.1, PXR.2, SAR, SXR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nr1i2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- ligand-dependent nuclear receptor interactor
- DNA binding domain
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- hinge domain
- Ligand-binding domain of nuclear hormone receptor
Pathways
Biological processes and signaling networks where the Nr1i2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- liver cancer
- uterine leiomyoma
- renal failure
- experimental inflammatory bowel disease
- hyperplasia
- microvesicular hepatic steatosis
- hepatomegaly
- liver failure
regulated by
- lipopolysaccharide
- D-glucose
- deoxycholate
- ethanol
- bile acid
- dexamethasone
- cyclophosphamide
- dihydromethysticin
- pregnenolone
- cisplatin
role in cell
- apoptosis
- activation in
- cell death
- expression in
- production in
- number
- phosphorylation in
- migration
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intermediate filament cytoskeleton
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nr1i2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of transcription, DNA-dependent
- steroid metabolic process
- xenobiotic catabolic process
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- xenobiotic metabolic process
- cell differentiation
- xenobiotic transport
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear body
- intermediate filament cytoskeleton
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity