Myo16 Gene Summary [Rat]
Enables actin filament binding activity and protein phosphatase binding activity. Involved in cerebellum development; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of cell population proliferation. Located in nucleoplasm; perinuclear region of cytoplasm; and plasma membrane. Part of myosin complex. Orthologous to human MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo16 |
| Official Name | myosin XVI [Source:RGD Symbol;Acc:621561] |
| Ensembl ID | ENSRNOG00000016483 |
| Bio databases IDs | |
| Aliases | myosin XVI |
| Synonyms | C230040D10Rik, Gm1105, mKIAA0865, MYAP3, Myo16b, myosin XVI, MYR8, NYAP3, PPP1R107 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myo16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
- Ankyrin repeats (many copies)
- Myosin and Kinesin motor domain
- protein phosphatase binding
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- Myosin head (motor domain)
- actin filament binding
- binding protein
- actin binding
- Myosin
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colorectal cancer
- systemic lupus erythematosus
- cleft lip
- idiopathic scoliosis
- insomnia
- prostate cancer
- preeclampsia
- Alzheimer disease
- dental caries
role in cell
- binding in
- proliferation
- activation in
- abnormal morphology
- remodeling
- remodeling in
- morphogenesis
- elongation in
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytoplasmic face of plasma membrane
- nucleoplasm
- membrane processes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myo16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase B signaling cascade
- cerebellum development
- negative regulation of cell proliferation
- neuron projection morphogenesis
- negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- myosin complex
- perinuclear region of cytoplasm
- cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein phosphatase binding
- protein binding
- motor activity