Enc1 Gene Summary [Rat]
Involved in positive regulation of neuron projection development. Located in chromatin; neuronal cell body; and nuclear lumen. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enc1 |
| Official Name | ectodermal-neural cortex 1 [Source:RGD Symbol;Acc:1303152] |
| Ensembl ID | ENSRNOG00000016541 |
| Bio databases IDs | |
| Aliases | ectodermal-neural cortex 1 |
| Synonyms | CCL28, ECTODERMAL-NEURAL CORTEX 1, KLHL35, KLHL37, NRPB, PIG10, TP53I10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Enc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- peptidase
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Pathways
Biological processes and signaling networks where the Enc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hairy cell leukemia
- early missed abortion
- colon cancer
- colorectal adenoma
- colorectal adenoma formation
- androgenic alopecia
- epileptic seizure
- infection by HIV-1
regulates
- NQO1
- CEACAM5
role in cell
- formation
- growth
- differentiation
- development
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- actin filaments
- nucleoplasm
- nucleoli
- nuclear matrix
- chromatin
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Enc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- positive regulation of neuron projection development
- negative regulation of translation
- proteasomal ubiquitin-independent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- nuclear matrix
- Cul3-RING ubiquitin ligase complex
- neuronal cell body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding