Nqo1 Gene Summary [Rat]
Enables NAD(P)H dehydrogenase (quinone) activity; NADH:ubiquinone reductase (non-electrogenic) activity; and superoxide dismutase activity. Involved in several processes, including regulation of apoptotic process; response to ischemia; and response to tetrachloromethane. Located in dendrite and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including cerebrovascular disease (multiple); liver disease (multiple); overactive bladder syndrome; status epilepticus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nqo1 |
| Official Name | NAD(P)H quinone dehydrogenase 1 [Source:RGD Symbol;Acc:2503] |
| Ensembl ID | ENSRNOG00000012772 |
| Bio databases IDs | |
| Aliases | NAD(P)H quinone dehydrogenase 1 |
| Synonyms | DHQU, DIA4, DTD, DT-diaphorase, NAD DT-diaphorase, Nadph dehydrogenase, NAD(P)H dehydrogenase, quinone 1, Nadph diaphorase, NAD(P)H quinone dehydrogenase 1, NAD(P)H:quinone oxidoreductase, Nadph Quinone Oxidoreductase-1, NMO1, NMOR, NMOR1, NMORI, Nqo, Ox-1, Qr, QR1, Quinone reductase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nqo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- superoxide dismutase
- NADH dehydrogenase (quinone)
- NAD(P)H2 dehydrogenase (quinone)
- cytochrome-b5 reductase
- enzyme
- protein binding
- identical protein binding
- hsp70 binding domain
- Flavodoxin-like fold
- NADPH-dependent FMN reductase
Pathways
Biological processes and signaling networks where the Nqo1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute lymphoblastic lymphoma
- leukemia
- neoplasia
- metastasis
- epithelial neoplasia
- epithelial cancer
- cancer
- non-insulin-dependent diabetes mellitus
- liver neoplasia
phenotypes
- Acute Lung Injury
- Brain Injuries
- Carbon Tetrachloride Poisoning
- Cerebral Hemorrhage
- Chemical and Drug Induced Liver Injury
- Chromosome 8 Trisomy
- Diabetic Nephropathies
- Experimental Arthritis
- Experimental Liver Neoplasms
- Hyperoxia
- Hyperoxic Lung Injury
- Intestinal Reperfusion Injury
- Kidney Reperfusion Injury
- Lead Poisoning
- Left Ventricular Hypertrophy
- Lung Injury
- Lung Neoplasms
- Lung Reperfusion Injury
- Mercury Poisoning
- Overactive Urinary Bladder
- Pancreatitis Experimental Chronic
- Spinal Cord Injuries
- Subarachnoid Hemorrhage
- acute kidney failure
- acute myeloid leukemia
- asthma
- breast cancer
- Cholestasis
- chronic kidney disease
- chronic myeloid leukemia
- chronic obstructive pulmonary disease
- colon cancer
- fatty liver disease
- hypertension
- Leukemia
- liver benign neoplasm
- Liver Cirrhosis
- lung disease
- Macular Degeneration
- membranous glomerulonephritis
- mental depression
- middle cerebral artery infarction
- Multiple Myeloma
- myelodysplastic syndrome
- myeloid neoplasm
- neurodegenerative disease
- non-small cell lung carcinoma
- Non-alcoholic Fatty Liver Disease
- precursor lymphoblastic lymphoma/leukemia
- Prostatitis
- Pulmonary Emphysema
- Renal Fibrosis
- small cell carcinoma
- Status Epilepticus
- transient cerebral ischemia
- Ureteral Obstruction
- urinary bladder cancer
- urinary system cancer
- visual epilepsy
- Experimental Pancreatitis Chronic
- lung non-small cell carcinoma
- acute lymphoblastic leukemia
role in cell
- cell death
- phosphorylation in
- cellular infiltration by
- production in
- apoptosis
- proliferation
- expression in
- number
- quantity
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nqo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- negative regulation of protein catabolic process
- ubiquinone metabolic process
- response to toxin
- positive regulation of neuron apoptotic process
- response to oxidative stress
- response to ethanol
- response to ischemia
- vitamin E metabolic process
- cellular response to hydrogen peroxide
- response to testosterone stimulus
- response to electrical stimulus
- protein catabolic process
- response to amine stimulus
- protein polyubiquitination
- response to carbohydrate stimulus
- response to nutrient
- cell redox homeostasis
- response to alkaloid
- NADH oxidation
- response to hormone stimulus
- negative regulation of apoptotic process
- innate immune response
- removal of superoxide radicals
- xenobiotic metabolic process
- vitamin K metabolic process
- response to estradiol stimulus
- cellular response to metal ion
- NADPH oxidation
- cellular response to oxidative stress
- response to lipopolysaccharide
- nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- cytosol
- neuronal cell body
- synapse
Molecular Function
What the gene product does at the molecular level
- cytochrome-b5 reductase activity
- identical protein binding
- NADH dehydrogenase (quinone) activity
- RNA binding
- protein binding
- NAD(P)H dehydrogenase (quinone) activity
- NADPH dehydrogenase (quinone) activity
- superoxide dismutase activity