Zfp276 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in kinetochore. Orthologous to human ZNF276 (zinc finger protein 276). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp276 |
| Official Name | zinc finger protein (C2H2 type) 276 [Source:RGD Symbol;Acc:1307469] |
| Ensembl ID | ENSRNOG00000016631 |
| Bio databases IDs | |
| Aliases | zinc finger protein (C2H2 type) 276 |
| Synonyms | CENP-Z, D8Ertd370e, D8Ertd377e, ZADT, ZFP276, zinc finger protein 276, zinc finger protein (C2H2 type) 276, ZNF477 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp276 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- double-stranded DNA binding
- Zinc-finger associated domain (zf-AD)
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-melanoma skin cancer
- epithelial cancer
- epithelial basal cell carcinoma
- metastasis
- organismal death
- dermatological disorder
- osteoarthritis
- melanoma cancer
- breast cancer
role in cell
- expression in
- migration
- proliferation
- invasion by
- Wnt signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp276 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- kinetochore
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- chromatin insulator sequence binding