Ccnd1 Gene Summary [Rat]
Enables protein kinase binding activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and response to vitamin E. Predicted to be located in bicellular tight junction and nucleoplasm. Predicted to be part of cyclin D1-CDK4 complex; cyclin D1-CDK6 complex; and transcription repressor complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Used to study prostate cancer and status epilepticus. Biomarker of atherosclerosis; impotence; interstitial cystitis; liver cancer; and transitional cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnd1 |
| Official Name | cyclin D1 [Source:RGD Symbol;Acc:68384] |
| Ensembl ID | ENSRNOG00000020918 |
| Bio databases IDs | |
| Aliases | cyclin D1 |
| Synonyms | B-CELL CLL/LYMPHOMA 1, BCL1, cD1, CycD1, CYCLIN D1, Cyl-1, D11S287E, G1/S-Specific Cyclin D1, PRAD1, U21B31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccnd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- cyclin box
- LXXLL motif
- protein kinase binding
- nuclear export signal
- Cyclin box fold superfamily
- transcription co-repressor
- nuclear localization sequence
- enzyme binding
- histone deacetylase binding
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- LXCXE binding site
- cyclin-dependent protein kinase regulator
- cyclin-dependent kinase binding domain
- phosphorylation site
- protein kinase activator
- PEST domain
- transcription repression domain
- binding protein
- destruction box
- Cyclin, N-terminal domain
- helix-loop-helix domain
Pathways
Biological processes and signaling networks where the Ccnd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Aryl Hydrocarbon Receptor Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Cyclins and Cell Cycle Regulation
- Docosahexaenoic Acid (DHA) Signaling
- EIF2 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- ErbB2-ErbB3 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Estrogen-mediated S-phase Entry
- GADD45 Signaling
- Glioma Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-7 Signaling Pathway
- Non-Small Cell Lung Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Small Cell Lung Cancer Signaling
- Thyroid Cancer Signaling
- TR/RXR Activation
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- neoplasia
- metastasis
- squamous cell lung cancer
- hepatocellular carcinoma
- non-small cell lung cancer
- organismal death
- prostate cancer
- plasma cell myeloma
- cancer
role in cell
- survival
- migration
- expression in
- radioresistance
- size
- adipogenesis
- phosphorylation in
- senescence
- cell death
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- basal compartment
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- tight junctions
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccnd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lactation
- fat cell differentiation
- response to xenobiotic stimulus
- regulation of cyclin-dependent protein kinase activity
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- re-entry into mitotic cell cycle
- cell division
- response to UV-A
- mammary gland alveolus development
- endoplasmic reticulum unfolded protein response
- G1/S transition of mitotic cell cycle
- mammary gland epithelial cell proliferation
- Wnt receptor signaling pathway
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of cyclin-dependent protein kinase activity
- positive regulation of G1/S transition of mitotic cell cycle
- neuron differentiation
- mitotic cell cycle G1/S transition DNA damage checkpoint
- response to leptin stimulus
- response to DNA damage stimulus
- negative regulation of epithelial cell differentiation
- positive regulation of protein phosphorylation
- positive regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- nuclear membrane
- centrosome
- cytoplasm
- transcriptional repressor complex
- cyclin D1-CDK4 complex
- cyclin-dependent protein kinase holoenzyme complex
- cytosol
- cyclin D1-CDK6 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- protein kinase binding
- cyclin-dependent protein kinase regulator activity
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- protein kinase activity
- enzyme binding