Nfkb1 Gene Summary [Rat]
Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to cytokine stimulus; and cellular response to diterpene. Acts upstream of or within cellular response to cytokine stimulus. Part of protein-containing complex. Used to study steatotic liver disease. Biomarker of alcoholic hepatitis; hepatocellular carcinoma; metabolic dysfunction-associated steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis; carcinoma (multiple); common variable immunodeficiency 12; melanoma; and prostate cancer. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkb1 |
| Official Name | nuclear factor kappa B subunit 1 [Source:RGD Symbol;Acc:70498] |
| Ensembl ID | ENSRNOG00000023258 |
| Bio databases IDs | |
| Aliases | nuclear factor kappa B subunit 1 |
| Synonyms | CVID12, EBP-1, KBF1, NF-kappa-B, NF-kappa-B1, Nf kappa b DNA binding subunit, NF-kappabeta, NF KAPPA B subunit P50, NF-kB, NFKB subunit P105/P50, NF-κ-B, NF-κ-B1, Nf κ b DNA binding subunit, NF κ B subunit P50, NUCLEAR FACTOR KAPPA B DNA binding subunit, nuclear factor kappa B subunit 1, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105, nuclear factor of κ light polypeptide gene enhancer in B cells 1, p105, NUCLEAR FACTOR κ B DNA binding subunit, nuclear factor κ B subunit 1, p105 Nfkb, p50 NF-kappaB, P50 nf κ b, P50/P105 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nfkb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- transcription regulator
- Ankyrin repeats (many copies)
- cell penetrating signal sequence
- Rel homology dimerization domain
- heat shock protein binding
- transcription cofactor
- transcription activation domain
- transcription factor binding
- chromatin binding
- identical protein binding
- Ankyrin repeat
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- ankyrin repeats
- glycine rich domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- dimerization domain
- DNA binding domain
- nucleic acid binding
- IPT
- actinin binding
- signal response domain
- nuclear localization sequence
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- DNA binding
- PEST domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- binding protein
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- Death Domain Superfamily of protein-protein interaction domains
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfkb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- Cancer Drug Resistance By Drug Efflux
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-9 Signaling
- Induction of Apoptosis by HIV1
- Inflammasome pathway
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- LXR/RXR Activation
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- PEDF Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Small Cell Lung Cancer Signaling
- Th1 Pathway
- Th2 Pathway
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary open-angle glaucoma
- diarrhea
- neoplasia
- COVID-19
- cerebral hemorrhage
- Huntington disease
- prostate cancer
- fibrosis
- interstitial fibrosis
- rheumatoid arthritis
role in cell
- cell viability
- migration
- expression in
- phosphorylation in
- growth
- activation in
- cell death
- formation in
- production in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- nuclear matrix
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nfkb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- negative regulation of calcidiol 1-monooxygenase activity
- cellular response to interleukin-6
- positive regulation of transcription, DNA-dependent
- apoptotic process
- negative regulation of vitamin D biosynthetic process
- cellular response to dsRNA
- cellular response to stress
- cellular response to tumor necrosis factor
- response to muscle stretch
- negative regulation of protein metabolic process
- cellular response to nicotine
- B cell receptor signaling pathway
- positive regulation of miRNA metabolic process
- mammary gland involution
- negative regulation of inflammatory response
- positive regulation of canonical Wnt receptor signaling pathway
- NIK/NF-kappaB cascade
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of hyaluronan biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- cellular response to mechanical stimulus
- cellular response to lipopolysaccharide
- negative regulation of apoptotic process
- innate immune response
- cellular response to interleukin-1
- negative regulation of cholesterol transport
- negative regulation of interleukin-12 production
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- extracellular region
- chromatin
- nucleoplasm
- transcription factor complex
- nucleus
- cytoplasm
- mitochondrion
- NF-kappaB p50/p65 complex
- cytosol
- secretory granule lumen
- I-kappaB/NF-kappaB complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- actinin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- sequence-specific DNA binding transcription factor activity
- transcription cofactor activity
- protein binding