Sap130 Gene Summary [Rat]
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic placenta development. Predicted to be located in nuclear speck. Predicted to be part of Sin3-type complex. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sap130 |
| Official Name | Sin3A associated protein 130 [Source:RGD Symbol;Acc:1311657] |
| Ensembl ID | ENSRNOG00000016773 |
| Bio databases IDs | |
| Aliases | Sin3A associated protein 130 |
| Synonyms | 2610304F09RIK, 6720406D06, RGD1311657, Sin3A associated protein, Sin3A associated protein 130 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sap130 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- Histone deacetylase complex subunit SAP130 C-terminus
Pathways
Biological processes and signaling networks where the Sap130 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chromosomal instability
- coronary artery disease
regulated by
- 2,4,5,2',4',5'-hexachlorobiphenyl
- bisphenol A
- laduviglusib
- levodopa
- monobutyl phthalate
regulates
- histone H4
- histone H3
- luciferase reporter gene
- synthetic promoter
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- CLEC4E
role in cell
- accumulation in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sap130 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- Sin3-type complex