Tiparp Gene Summary [Rat]
Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein-cysteine ADP-ribosyltransferase activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in response to 2,3,7,8-tetrachlorodibenzodioxine. Predicted to be active in nucleus. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tiparp |
| Official Name | TCDD-inducible poly(ADP-ribose) polymerase [Source:RGD Symbol;Acc:1306171] |
| Ensembl ID | ENSRNOG00000011238 |
| Bio databases IDs | |
| Aliases | TCDD-inducible poly(ADP-ribose) polymerase |
| Synonyms | ARTD14, DKFZP434J214, LOC102724343, LOC107986148, PARP7, pART14, RM1, TCDD-inducible poly(ADP-ribose) polymerase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tiparp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentosyltransferase
- catalytic domain
- NAD ADP-ribosyltransferase
- double-stranded DNA binding
- nucleic acid binding
- Poly(ADP-ribose) polymerase catalytic domain
- WWE domain
- enzyme
- sequence-specific DNA binding
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the Tiparp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- ovarian carcinoma
- epithelial ovarian cancer
- systemic autoimmune syndrome
- splenomegaly
- epileptic seizure
- diabetic nephropathy
- meningioma
role in cell
- expression in
- molecular cleavage in
- binding in
- cellular infiltration by
- hematopoiesis
- ADP ribosylation in
- late stage apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tiparp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen metabolic process
- hemopoiesis
- post-embryonic development
- palate development
- positive regulation of protein catabolic process
- platelet-derived growth factor receptor signaling pathway
- smooth muscle tissue development
- female gonad development
- vasculogenesis
- skeletal system morphogenesis
- face morphogenesis
- negative regulation of gene expression
- androgen metabolic process
- kidney development
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- metal ion binding
- core promoter proximal region sequence-specific DNA binding
- NAD+ ADP-ribosyltransferase activity