P4ha3 Gene Summary [Rat]
Enables procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P4ha3 |
| Official Name | prolyl 4-hydroxylase subunit alpha 3 [Source:RGD Symbol;Acc:735150] |
| Ensembl ID | ENSRNOG00000017118 |
| Bio databases IDs | |
| Aliases | prolyl 4-hydroxylase subunit alpha 3 |
| Synonyms | D930031A02Rik, procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III, procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), α polypeptide III, prolyl 4-hydroxylase subunit alpha 3, prolyl 4-hydroxylase subunit α 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat P4ha3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- procollagen-proline dioxygenase
- enzyme
- protein binding
- Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Pathways
Biological processes and signaling networks where the P4ha3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- acute myeloid leukemia
- breast carcinoma
- epithelial cancer
- epithelial neoplasia
- head and neck squamous cell cancer
- glioblastoma
- glioblastoma cancer
- squamous cell lung cancer
- hepatocellular carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat P4ha3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- procollagen-proline 4-dioxygenase activity
- L-ascorbic acid binding
- protein binding
- iron ion binding