Epor Gene Summary [Rat]
Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of nitric oxide biosynthetic process; and positive regulation of ERK1 and ERK2 cascade. Located in external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epor |
| Official Name | erythropoietin receptor [Source:RGD Symbol;Acc:2560] |
| Ensembl ID | ENSRNOG00000012619 |
| Bio databases IDs | |
| Aliases | erythropoietin receptor |
| Synonyms | EPO receptor, erythropoietin receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epor often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- Fibronectin type 3 domain
- identical protein binding
- Stat5 binding domain
- YXXP domain
- Box I domain
- Box II domain
- cytoplasmic domain
- Jak2 binding domain
- intracellular domain
- transmembrane receptor
- Shp1 binding domain
- extracellular domain
- dimerization domain
- erythropoietin receptor
- ectodomain
- negative regulatory domain
- protein binding
- Src-homology 2 binding domain
- phosphotyrosine motif
- Sh Ptp1 binding domain
- FN3
- transmembrane/cytoplasmic domain
- transmembrane domain
- signaling domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Epor gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- kidney disease
- renal failure
- diabetic nephropathy
- heart failure
- left ventricular hypertrophy
- cardiovascular disorder
- acute myocardial infarction
- HIV infection
- chronic renal impairment
role in cell
- growth
- expression in
- apoptosis
- cell viability
- proliferation
- activation in
- phosphorylation in
- survival
- colony formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane extracellular face
- nuclear speckles
- perikaryon
- dendrites
- presynaptic terminals
- rod inner segments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epor gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- signal transduction
- cytokine-mediated signaling pathway
- hemopoiesis
- positive regulation of cell proliferation
- decidualization
- erythropoietin-mediated signaling pathway
- brain development
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- erythropoietin receptor activity
- identical protein binding
- protein binding