Hikeshi Gene Summary [Rat]
Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Predicted to be involved in cellular response to heat and protein import into nucleus. Predicted to act upstream of or within Golgi organization and lung development. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hikeshi |
| Official Name | heat shock protein nuclear import factor [Source:RGD Symbol;Acc:1359455] |
| Ensembl ID | ENSRNOG00000017383 |
| Bio databases IDs | |
| Aliases | heat shock protein nuclear import factor |
| Synonyms | 0610007P06Rik, 1110002N09Rik, C11orf73, heat shock protein nuclear import factor, heat shock protein nuclear import factor hikeshi, HLD13, HSPC138, HSPC179, l(7)6Rn, L7RN6, OPI10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hikeshi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- protein binding
- Protein of unknown function (DUF775)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hikeshi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- protein import into nucleus
- Golgi organization
- protein transport
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- Hsp70 protein binding