Cul5 Gene Summary [Rat]
Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in regulation of cytosolic calcium ion concentration. Predicted to be located in site of DNA damage. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cul5 |
| Official Name | cullin 5 [Source:RGD Symbol;Acc:621742] |
| Ensembl ID | ENSRNOG00000008039 |
| Bio databases IDs | |
| Aliases | cullin 5 |
| Synonyms | 4921514I20Rik, 8430423K24Rik, C030032G03Rik, C330021I08Rik, cullin 5, VACM-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cul5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- signaling receptor activity
- vasopressin receptor
- calcium channel
- ubiquitin-protein transferase activity
- protein binding activity, bridging
- Cullin protein neddylation domain
- Cullin family
- protein binding
- ion channel
- Cullin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- airway hyperresponsiveness
- luminal A breast carcinoma
- luminal A breast cancer
- hyperplasia
- scarlet fever
- infection by vesicular stomatitis virus
role in cell
- differentiation
- proliferation
- apoptosis
- migration
- cellular infiltration by
- accumulation
- expression in
- production in
- quantity
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cul5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G1/S transition of mitotic cell cycle
- calcium ion transmembrane transport
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- intrinsic apoptotic signaling pathway
- ERBB2 signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- SCF ubiquitin ligase complex
- Cul5-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- calcium channel activity
- signaling receptor activity
- protein binding, bridging