P2rx1 Gene Summary [Rat]
Enables anion binding activity; extracellularly ATP-gated monoatomic cation channel activity; and identical protein binding activity. Involved in several processes, including neuronal action potential; positive regulation of calcium ion import across plasma membrane; and regulation of presynaptic cytosolic calcium ion concentration. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2rx1 |
| Official Name | purinergic receptor P2X 1 [Source:RGD Symbol;Acc:3240] |
| Ensembl ID | ENSRNOG00000017606 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2X 1 |
| Synonyms | P2x, P2X1, P2XMR, PDCD3, purinergic receptor P2X 1, purinergic receptor P2X, ligand-gated ion channel, 1, RP-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat P2rx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- calcium channel
- ATP P2X receptor
- ATP binding
- protein binding
- identical protein binding
- ion channel
- binding protein
- purinergic nucleotide receptor
- transmembrane domain
- ligand-gated ion channel
- ATP-gated cation channel
- cation channel
Pathways
Biological processes and signaling networks where the P2rx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycystic kidney disease
- mitochondrial disorder
- drug-induced liver disease
role in cell
- migration
- expression in
- cell death
- recruitment
- localization
- replication in
- formation
- activation
- contraction
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cellular membrane
- secretory granule membrane
- specific granule membrane
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat P2rx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- purinergic nucleotide receptor signaling pathway
- response to ATP
- signal transduction
- ceramide biosynthetic process
- insemination
- regulation of vascular smooth muscle contraction
- regulation of blood pressure
- serotonin secretion by platelet
- ion transport
- apoptotic process
- calcium ion transmembrane transport
- regulation of synaptic vesicle exocytosis
- calcium-mediated signaling
- platelet activation
- synaptic transmission, glutamatergic
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- postsynaptic membrane
- membrane raft
- external side of plasma membrane
- macromolecular complex
- presynaptic active zone membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- extracellular ATP-gated cation channel activity
- ATP binding
- identical protein binding
- protein binding
- suramin binding
- purinergic nucleotide receptor activity
- cation channel activity