Pi4k2a Gene Summary [Rat]
Enables 1-phosphatidylinositol 4-kinase activity. Involved in basophil degranulation. Located in several cellular components, including cytoplasmic vesicle membrane; growing cell tip; and perikaryon. Part of protein-containing complex. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pi4k2a |
| Official Name | phosphatidylinositol 4-kinase type 2 alpha [Source:RGD Symbol;Acc:620485] |
| Ensembl ID | ENSRNOG00000014675 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol 4-kinase type 2 alpha |
| Synonyms | NEDMSB, phosphatidylinositol 4-kinase type 2 alpha, phosphatidylinositol 4-kinase type 2 α, Pi4k2, PI4KII, PIK42A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pi4k2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- 1-phosphatidylinositol 4-kinase
- binding protein
- Protein Kinases, catalytic domain
- Phosphatidylinositol 3- and 4-kinase
- ATP binding
- protein binding
Pathways
Biological processes and signaling networks where the Pi4k2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- papillary thyroid cancer
- fibrosarcoma
- follicular thyroid carcinoma
- papillary thyroid carcinoma
- melanoma
- melanoma cancer
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- expression in
- phosphorylation in
- accumulation in
- formation
- degranulation
- migration
- production in
- formation in
- alpha 2,3 sialylation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- glutaminergic synapse
- exocytic vesicle
- presynaptic regions
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Mitochondria
- granules
- cytosol
- microsome
- presynaptic membrane
- Golgi membrane
- endosomal compartment
- endosomal membrane
- neurites
- nerve ending
- synapse
- early endosomes
- late endosomes
- cytoplasmic vesicles
- synaptic-like microvesicles
- cell tip
- membrane rafts
- membrane processes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pi4k2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- Golgi organization
- phosphatidylinositol phosphorylation
- phosphatidylinositol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- BLOC-1 complex
- Golgi membrane
- neuronal cell body
- perikaryon
- neuron projection
- lysosomal membrane
- plasma membrane
- early endosome membrane
- dendrite
- trans-Golgi network
- endosome
- growing cell tip
- membrane raft
- mitochondrion
- membrane
- cytosol
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- AP-3 adaptor complex binding
- protein binding
- 1-phosphatidylinositol 4-kinase activity