Fas Gene Summary [Rat]
Enables protease binding activity; protein phosphatase binding activity; and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to cobalt ion; cellular response to cytokine stimulus; and nervous system development. Located in several cellular components, including apical dendrite; external side of plasma membrane; and sarcolemma. Part of CD95 death-inducing signaling complex. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fas |
| Official Name | Fas cell surface death receptor [Source:RGD Symbol;Acc:619831] |
| Ensembl ID | ENSRNOG00000019142 |
| Bio databases IDs | |
| Aliases | Fas cell surface death receptor |
| Synonyms | ALPS1A, APO-1, APT1, CD95, CD95L, CD95 receptor, FAS1, FAS/APO1, Fas cell surface death receptor, FasR, FASTM, lpr, Receptor for Fas Ligand, Receptors for Fas Ligand, TNFR6, Tnf receptor member 6, TNFRSF6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fas often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- cytotoxicity domain
- identical protein binding
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- transmembrane receptor
- cysteine rich domain
- extracellular domain
- signaling receptor activity
- calmodulin binding
- protease binding
- protein phosphatase binding
- ectodomain
- TNFR/NGFR cysteine-rich region
- protein binding
- Fc domain
- Tumor necrosis factor receptor superfamily (TNFRSF)
- ezrin binding domain
- pre-ligand assembly domain
- binding protein
- kinase binding
- FADD binding domain
- tumor necrosis factor receptor
- transmembrane domain
- cytosolic tail domain
- PDZ binding motif
- Death Domain Superfamily of protein-protein interaction domains
- death domain binding domain
Pathways
Biological processes and signaling networks where the Fas gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Apelin Liver Signaling Pathway
- Apoptosis Signaling
- Aryl Hydrocarbon Receptor Signaling
- Autoimmune Thyroid Disease Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Graft-versus-Host Disease Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-4 Signaling
- Induction of Apoptosis by HIV1
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- p38 MAPK Signaling
- p53 Signaling
- PEDF Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Tec Kinase Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- diabetes mellitus
- non-small cell lung carcinoma
- septic shock
- sepsis
- neoplasia
- plasma cell myeloma
- experimental autoimmune encephalomyelitis
- liver cancer
- epithelial cancer
role in cell
- expression in
- activation
- inhibition in
- migration
- cell death
- activation in
- molecular cleavage in
- proliferation
- binding in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- soluble fraction
- Golgi-enriched fraction
- membrane fraction
- insoluble fractions
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- cytosol
- sarcoplasm
- basolateral cell surfaces
- plasma membrane extracellular face
- apical membrane
- nuclear bodies
- neurites
- sarcolemma
- anchoring junction
- secretory granules
- membrane rafts
- membrane processes
- perikaryon
- axons
- cell-cell adherens junctions
- plasma
- apical processes
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fas gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- signal transduction
- cellular response to amino acid starvation
- extrinsic apoptotic signaling pathway
- regulation of apoptotic process
- extrinsic apoptotic signaling pathway in absence of ligand
- activation-induced cell death of T cells
- cellular response to mechanical stimulus
- tumor necrosis factor-mediated signaling pathway
- immune response
- motor neuron apoptotic process
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- apoptotic process
- regulation of stress-activated MAPK cascade
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- cellular response to hyperoxia
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- nuclear body
- membrane raft
- external side of plasma membrane
- cytosol
- death-inducing signaling complex
- CD95 death-inducing signaling complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- identical protein binding
- protein binding
- tumor necrosis factor-activated receptor activity
- signaling receptor activity
- kinase binding