Uros Gene Summary [Rat]
Enables folic acid binding activity. Contributes to uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to arsenic-containing substance; response to platinum ion; and uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Used to study cutaneous porphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uros |
| Official Name | uroporphyrinogen III synthase [Source:RGD Symbol;Acc:1310396] |
| Ensembl ID | ENSRNOG00000017810 |
| Bio databases IDs | |
| Aliases | uroporphyrinogen III synthase |
| Synonyms | AI415298, UROIIIS, uroporphyrinogen III synthase, Uros3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uros often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uroporphyrinogen-III synthase
- folic acid binding
- enzyme
- HemD
- Uroporphyrinogen-III synthase HemD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uros gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme O biosynthetic process
- response to platinum ion
- uroporphyrinogen III biosynthetic process
- cellular response to arsenic-containing substance
- heme biosynthetic process
- heme a biosynthetic process
- protoporphyrinogen IX biosynthetic process
- cellular response to amine stimulus
- heme b biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- folic acid binding
- uroporphyrinogen-III synthase activity