Ccn5 Gene Summary [Rat]
Enables integrin binding activity. Involved in negative regulation of cell population proliferation. Located in cell surface; nucleus; and podosome. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccn5 |
| Official Name | cellular communication network factor 5 [Source:RGD Symbol;Acc:621867] |
| Ensembl ID | ENSRNOG00000010666 |
| Bio databases IDs | |
| Aliases | cellular communication network factor 5 |
| Synonyms | cellular communication network factor 5, CRGR4, CT58, CTGF-L, Rcop1, WISP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccn5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- integrin binding
- protein binding
- Spondin-like TSP1 domain
- Insulin-like growth factor binding protein
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- epithelial cancer
- prostate cancer
- liver cancer
- invasive breast carcinoma
- acute myeloid leukemia
- lung adenocarcinoma
- lung adenocarcinoma formation
- colon adenocarcinoma
- colon epithelial cancer
role in cell
- expression in
- activation in
- migration
- phosphorylation in
- morphology
- proliferation
- apoptosis
- adhesion
- growth
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- podosomes
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccn5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- positive regulation of cell differentiation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding
- integrin binding