Mvb12a Gene Summary [Rat]
Predicted to enable lipid binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in centrosome; intracellular membrane-bounded organelle; and vesicle. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to human MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mvb12a |
| Official Name | multivesicular body subunit 12A [Source:RGD Symbol;Acc:735220] |
| Ensembl ID | ENSRNOG00000017949 |
| Bio databases IDs | |
| Aliases | multivesicular body subunit 12A |
| Synonyms | 1110012M11Rik, CFBP, FAM125A, LOC100507535, multivesicular body subunit 12A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mvb12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- Multivesicular body subunit 12
- ubiquitin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- vesicles
- centrosome
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mvb12a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- receptor catabolic process
- virus maturation
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- non-lytic virus budding
- endosome to lysosome transport via multivesicular body sorting pathway
- regulation of epidermal growth factor receptor signaling pathway
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- nucleus
- late endosome membrane
- centrosome
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- ESCRT I complex
- vesicle
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- lipid binding
- SH3 domain binding